SynthesisJournal of the American Heart Association2026
Echocardiographic Indices of Cardiac Remodeling Following Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Prognostic Value of Prolapse Width for Mid-Term Degenerative Mitral Regurgitation Stability After Transcatheter Edge-to-Edge Repair.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Transcatheter Therapy in Secondary Mitral Regurgitation: Recent Clinical Evidence and Emerging Frontiers.Cureus · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary mitral regurgitation is associated with adverse clinical outcomes and cardiac remodeling. While transcatheter edge-to-edge repair (TEER) improves symptoms and prognosis in selected patients, its effects on cardiac remodeling remain debated. This systematic review and meta-analysis aimed to evaluate the impact of TEER on echocardiographic indices of cardiac remodeling.
methodsPubMed, Scopus, and Cochrane Library were used to identify relevant studies assessing echocardiographic changes before and after TEER. Outcomes of interest were left ventricular (LV) ejection fraction, global longitudinal strain, LV end-diastolic and end-systolic volumes and LV end-diastolic and end-systolic diameter, tricuspid annular plane systolic excursion, pulmonary artery systolic pressure, and left atrial end-systolic volume.
resultsForty-two studies (3987 patients) were included. TEER was associated with a significant increase in LV ejection fraction (mean difference [MD], 1.51% [95% CI, 0.47-2.55]), without significant improvement in global longitudinal strain. Significant LV remodeling was observed, with reductions in LV end-diastolic volume (standardized MD, -0.26 [95% CI, -0.37 to -0.14]), LV end-systolic volume (standardized MD, -0.21 [95% CI, -0.30 to -0.12]), LV end-diastolic diameter (MD, -2.35 mm [95% CI, -3.66 to -1.04]) and left ventricular end-systolic diameter (MD, -2.30 mm [95% CI, -3.86 to -0.74). TEER also improved right ventricular function (tricuspid annular plane systolic excursion [MD, 1.29 mm [95% CI, 0.60-1.97]) and reduced pulmonary artery systolic pressure (MD, -6.75 mm Hg [95% CI, -8.53 to -4.97). No significant improvement in left atrial end-systolic volume was detected.
conclusionsAvailable evidence suggests that TEER promotes significant cardiac remodeling in patients with secondary mitral regurgitation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.