Evidence map›Paper›PMID 41669974›Full record

ArticleObesity (Silver Spring, Md.)2026

C/EBP α is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice.

Krista Y Hu, Yu-Lin Ma, Esme A Dodge, Olivia A B Maguire, Caio V Matias, Ryan P Barney, Hector S Himede, Juliana Gomez Pardo, Miriam Cepeda, Scott M Gordon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Krista Y HuCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Yu-Lin MaCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Esme A DodgeCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Olivia A B MaguireCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0002-0952-8798
Caio V MatiasCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0001-8321-5581
Ryan P BarneyDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Hector S HimedeCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Juliana Gomez PardoCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Miriam CepedaCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.
Scott M GordonDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Robert C BauerCardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0001-9752-9645

Funding

Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1986 to 2025
$2.1M
NUTRITIONT32DK007647 · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1990 to 2025
$1.7M
Molecular Mechanisms of TRIB1 Regulation of Hepatic MetabolismR01DK134026 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$599k
American Heart Association 23PRE1020947American Heart Association 23TPA1077613NHLBI NIH HHS R01 HL141745NHLBI NIH HHS R01HL141745NIDDK NIH HHS P30DK026887NIDDK NIH HHS R01 DK134026NIDDK NIH HHS R01DK134026NIDDK NIH HHS R01DK134026-02S1NIDDK NIH HHS T32 DK007328NIDDK NIH HHS T32DK007328NIDDK NIH HHS T32 DK007647NIDDK NIH HHS T32DK007647
6 · The paper itself

Abstract

objectiveThe distribution of excess white adipose tissue (WAT) in obesity correlates with risk for comorbidities. Thus, understanding depot-specific WAT developmental mechanisms is translationally relevant. SNPs near the gene CEBPA associate with waist to hip ratio, and while C/EBPα is a recognized regulator of adipogenesis, there is no previously known role for C/EBPα in regulating adipose distribution.

methodsWe crossed Cebpa floxed mice to the AdipoQ-Cre transgenic mouse strain, generating mice with adipocyte-specific knockout of Cebpa (Cebpa_ASKO). Mice were phenotyped on a chow diet and after prolonged high-fat diet (HFD) feeding.

resultsCebpa_ASKO mice almost entirely lack gonadal WAT (gWAT), while inguinal WAT (iWAT) is present in near normal amounts. Despite developing, Cebpa_ASKO iWAT contains fewer and larger adipocytes, fails to expand under HFD challenge, and is dysfunctional as evidenced by transcriptomics and functional studies. Finally, Cebpa_ASKO mice have lipid-laden brown adipose tissue (BAT), increased hepatic triglycerides, and increased plasma cholesterol, all of which worsen with prolonged HFD feeding.

conclusionsThese results highlight a previously unrecognized difference in the essentiality of C/EBPα for gWAT and iWAT development and highlight novel interorgan relationships between WAT and other metabolic tissues. Further studies of these specific mechanisms could have clinical relevance for targeting visceral adiposity in humans.

Indexed as

AdipogenesisAdipose Tissue, WhiteCCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding ProteinsAdipocytesAdipose Tissue, BrownAnimalsDiet, High-FatFemaleGonadsMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicObesityCCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding ProteinsCEBPA protein, mouseCEBPAGWAStranscription factorvisceral adiposeWAT development

Identifiers

PMID41669974
PMCPMC13032053

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.