ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026
Critique of a Radically New Model for Plasma Membrane Bilayer Organization.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Does Complexation of Plasma Membrane Cholesterol with Phospholipids Determine its Transbilayer Distribution?The Journal of membrane biology · 2026Article
- Membrane Models and the Pursuit of Coherence.Biochemistry · 2026Review
- Dark Side ofJournal of the American Chemical Society · 2026Article
- Critique of a Radically New Model for Plasma Membrane Bilayer Organization.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel model recently proposed by Doktorova et al. challenges current concepts for the molecular organization of the plasma membrane bilayer. It is at odds with previously published research. The model posits that there are far fewer phospholipid molecules in the outer leaflet of the bilayer than in the inner leaflet and that the resulting area deficit is filled by cholesterol. This conclusion is based on the incomplete hydrolysis of the phosphatidylcholine in intact erythrocytes by phospholipase A2, leading to the inference that the undigested fraction is endofacial. But the incomplete digestion can be explained by product inhibition. Furthermore, ultrastructural analysis has shown that almost all of the phosphatidylcholine in the erythrocyte bilayer resides in the outer leaflet. Finally, the high concentration of cholesterol predicted for the outer leaflet of resting human erythrocytes is not detectable by probes. The conflict of the new model with the literature makes it insecure.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.