ReviewCellular and molecular life sciences : CMLS2026
Beyond the membrane: rethinking EGFR signaling in physiology and cancer.
Review in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking.Life science alliance · 2026Article
- Synthesis, anti-proliferative evaluation, DFT,RSC advances · 2026Article
- Functional Specialization of Clathrin-Independent Endocytic Routes: Mechanisms and Cellular Roles.Traffic (Copenhagen, Denmark) · 2026Review
- Bioengineered systems to exploit tumor microenvironment metabolism.Trends in cancer · 2026Review
- Design, Synthesis, and Biological Evaluation of Amide Derivatives of Coumarin-1,2,4-Thiadiazoles as Anticancer Agents.Chemistry & biodiversity · 2026Article
- Design, synthesis, and biological characterization of a hydrophobic tagging EGFR degrader for the treatment of non-small-cell lung cancer.Molecular diversity · 2026Article
- Sensitive Detection of Epidermal Growth Factor in Lung Cancer Patients by Electrochemical Biosensors.Analytical chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The epidermal growth factor receptor (EGFR) functions as a central signaling hub that integrates biochemical and mechanical cues essential for tissue development, homeostasis, and disease. Emerging evidence highlights how EGFR activity is finely regulated through its spatial organization at the plasma membrane, intracellular trafficking pathways, and interactions with organelles via specialized membrane contact sites. In addition to its well-established ligand-dependent activation, EGFR also mediates ligand- and kinase-independent functions, adding further complexity to its roles in physiology and pathology, particularly in cancer. This review explores how ligand diversity, cellular context, and mechanical stimuli converge to shape EGFR signaling, emphasizing the integration of ligand-dependent and -independent mechanisms in determining cellular outcomes. We also discuss how these emerging functions influence cancer cell metabolism and survival. A deeper understanding of these intricate signaling networks may inform the development of novel therapeutic strategies to modulate EGFR activity in cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.