ArticleTissue engineering and regenerative medicine2026
Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries.
Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Adaptation of Non-Invasive Cancer Cells to 3D Collagen I Microenvironment Induces Transcriptional Reprogramming Accompanied by a More Complex RNA Landscape.International journal of molecular sciences · 2026Article
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6 authors.
Funding
Abstract
backgroundThe Stromal Vascular Fraction (SVF) derived from human subcutaneous fat has attracted pivotal interest in clinical applications for its regenerative and anti-inflammatory properties. A deeper characterisation of the endothelial cells within the SVF, across both traditional and tissue-engineered culture systems, is essential for advancing our understanding of endothelial cell biology and enhancing regenerative medicine therapies, including skin substitutes.
methodsThis study investigates endothelial cells from the SVF of human subcutaneous white adipose tissue in 2D culture and 3D bioengineered skin models to better define their specific subtypes. Immunofluorescence analysis was used to assess the SVF, with particular focus on endothelial cells, including their ability to form capillary-like networks within type I collagen hydrogels.
resultsAnalysis of the SVF-derived cells showed PLVAP-positive blood endothelial cells but no lymphatic endothelial cells. The blood endothelial cells could be discriminated into NR2F2- and CD62E-positive venous endothelial cells and NRP1-expressing arterial endothelial cells. Within the 3D hydrogels, the blood endothelial cells formed venous and arterial capillaries.
conclusionWe characterised endothelial cells from human subcutaneous SVF, identifying venous and arterial blood endothelial cells while confirming the absence of lymphatic endothelial cells in vitro. These findings underline that subcutaneous adipose tissue is an attractive cell source due to its ease of isolation and abundance of endothelial cells for skin tissue engineering and regenerative medicine in general.
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