ArticleVeterinary research communications2026
Butyric glycerides enhance resistance of chicken enterocytes to pathogen adhesion and cytotoxicity in vitro.
Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Butyrate is a short-chain fatty acid naturally produced by microbiota in the lower gut of chicken. It enhances gut integrity and maturity and acts as a primary energy source for enterocytes. To extend its benefits in chickens' digestive tract, protected butyrate sources are supplemented in the feed. The current study aims to characterize the effects of a mixture of mono-, di-, and triglycerides of butyrate on avian enterocyte resistance to pathogen colonization. This in vitro study shows that the butyric-glycerides (BG) mixture directly enhances the 8E11 chicken enterocytes' resistance to microbial pathogens. Unlike sodium butyrate (SB), treatments with butyric glycerides at 2 mM notably reduced the adhesion levels of Campylobacter jejuni and Salmonella Typhimurium to enterocytes by 84 and 60%, respectively (P < 0.001). Butyric glycerides also significantly reduced Clostridium perfringens α toxin-induced cytotoxicity, which reached 83% in untreated control group while only 28% of cytotoxicity is induced in presence of BG (P < 0.001). Secondly, only the butyrate released through lipolysis, rather than butyric glycerides themselves, was able to enhance the basal and maximal the oxygen consumption rate in chicken enterocytes by ~ 40 and 56% (P < 0.001). This mitochondrial metabolic response may lead to increased CO
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