SynthesisEndocrine2026
Female infertility and long-term cardiovascular risk: a systematic review and meta-analysis.
Synthesis in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interplay of Total Antioxidant Capacity and Oxidative Stress Hydroperoxides with Circulating Biomarkers of Inflammation and Iron Status According to Oral Contraception Use.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between a personal history of infertility and the risk for future cardiovascular disease (CVD) and related manifestations like coronary heart disease (CHD), cerebrovascular disease and heart failure in women. We also considered the potential influence of exposure to assisted reproductive technology (ART) on the risk of future CVD.
methodsThis systematic review and meta-analysis of 22 studies, registered in PROSPERO (CRD42023420300), followed PRISMA guidelines. Pooled odds ratios (OR) and hazard ratios (HR) were calculated using Mantel-Haenszel and inverse variance methods, while heterogeneity was evaluated using I². Sensitivity analyses were performed to explore the impact of study design.
resultsWe observed that women with infertility compared to controls had a higher risk of incident CVD (infertile vs controls: 178,828 vs 3,398,781; HR = 1.14, 95% CI 1.12-1.16; I² = 89%), CHD (HR=1.17, 95% CI 1.12-1.23; I² = 0%), and cerebrovascular events (HR=1.16, 95% CI 1.11-1.21; I²=73%). Exposure to ART was associated with a higher risk of overall CVD across five studies (HR = 1.17, 95% CI 1.11–1.24; I² = 96%) and with increased incident stroke across four studies (HR = 1.12, 95% CI 1.03–1.23; I² = 60%), whereas no significant association was observed with CHD. However, some of the estimates were heterogenous, which limits certainty and causal inference. DISCUSSION: Women with infertility compared with controls had higher pooled estimates for incident CVD, CHD and cerebrovascular events. However, these estimates were heterogeneous (I² up to 99%), which limits certainty and precludes causal inference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.