ArticleImmunity2026
Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells.
Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
Funding
Abstract
Type I interferons (IFN-I), including IFN-β and multiple IFN-α subtypes, are key antiviral proteins encoded within a single large locus. Here, we studied how the chromatin organization of this locus controls cell-type-specific IFN-I responses. The professional IFN-I-producing plasmacytoid dendritic cells (pDCs) simultaneously induced nearly all IFN-I subtypes across the locus. During pDC differentiation, the IFN-I locus translocated into the active intranuclear chromosomal compartment. It also underwent cohesin-dependent reorganization of its three-dimensional chromatin structure; accordingly, IFN-I production by pDCs was cohesin dependent. The promoters of most IFN-I genes harbored open chromatin peaks specifically in pDCs. The preemptive intranuclear translocation and promoter opening of IFN-I genes in pDCs were mediated by the pDC-enriched transcription factor interferon regulatory factor (IRF)8. Several IRF8- and/or cohesin-binding regulatory regions within the IFN-I locus facilitated IFN-I gene induction in pDCs, as confirmed by single-cell multiome analysis. Thus, the unique IFN-I-producing capacity of pDCs is facilitated by anticipatory chromatin organization imparted by IRF8 and cohesin.
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