Evidence map›Paper›PMID 41672513›Full record

ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2026

The Japanese gut microbiome: ecology, uniqueness, and impact on health and disease.

Suguru Nishijima, Masahira Hattori, Naoyoshi Nagata

Abstract readReview
In one paragraph

Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suguru NishijimaLife Science Data Research Center, The University of Tokyo.ORCID http://orcid.org/0000-0002-8444-9272
Masahira HattoriFaculty of Science and Engineering, Waseda University.ORCID http://orcid.org/0000-0001-9467-0344
Naoyoshi NagataCenter for Health Surveillance and Preventive Medicine, Tokyo Medical University.ORCID http://orcid.org/0000-0002-7255-4024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metagenomics has become a powerful approach for deciphering the structure and function of the human gut microbiome, a complex microbial ecosystem in the gut. The human gut microbiome plays a crucial role in health and disease through multifaceted interactions with various factors, including age, diet, lifestyle, and medications. This review summarizes key advances in gut microbiome research over the past two decades and presents several topics from a recent large-scale, data-driven study, specifically a cohort-based initiative, the Japanese 4D microbiome project. These include a population-level characterization of the Japanese gut microbiome in a global context through comparison with 31,695 gut metagenomes from 37 countries, as well as an extensive analysis of the effects of medications. This review provides new insights into the ecology and uniqueness of the Japanese gut microbiome and highlights the importance of large-scale, well-phenotyped cohorts in advancing microbiome science.

Indexed as

DiseaseGastrointestinal MicrobiomeHealthEast Asian PeopleHumansJapanMetagenomeMetagenomicsJapanese gut microbiomelarge-scalelifestylemetagenomicspolypharmacyprecision medicine

Identifiers

PMID41672513
PMCPMC13000112

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.