Evidence map›Paper›PMID 41673107›Full record

ArticleScientific reports2026

SCARF1 deficiency exacerbates gut inflammation and autoimmune pathology.

Dominique M Shepard, Sabine Hahn, Monika Chitre, Haley Neff, Doyle V Ward, Nupur Jadhav, Jillian M Richmond, Zaida G Ramirez-Ortiz

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dominique M ShepardDepartment of Medicine, Division of Infectious Disease and Immunology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, US.
Sabine HahnDepartment of Medicine, Division of Infectious Disease and Immunology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, US.
Monika ChitreDepartment of Medicine, Division of Infectious Disease and Immunology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, US.
Haley NeffDepartment of Dermatology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, USA.
Doyle V WardDepartment of Microbiology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, USA.
Nupur JadhavDepartment of Pathology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, USA.
Jillian M RichmondDepartment of Dermatology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, USA.
Zaida G Ramirez-OrtizDepartment of Medicine, Division of Infectious Disease and Immunology, University of Massachusetts Chan Medical School, 364 Plantation St, 01605, Worcester, MA, US. Zaida.RamirezOrtiz@umassmed.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease known for its heterogeneity in both manifestation and presentation. Recent evidence has increasingly implicated the gut microbiome within immunomodulation and autoimmunity. This study aims to characterize the intestinal inflammation and microbial profile associated with autoimmune diseases, particularly SLE, and to identify unique biomarkers and shared microbial signatures for potential therapeutic measures. Our lab identified scavenger receptor class F, member 1 (SCARF1, SREC-1) as an efferocytosis receptor essential for the clearance of apoptotic debris, and its deficiency results in the development of lupus-like disease. SCARF1 is crucial in immune homeostasis, and defects in efferocytosis lead to inflammation. However, the role of SCARF1 in gut homeostasis remains to be elucidated. To answer our question, we analyzed and compared the metagenomic datasets generated through whole genome shotgun sequencing between our Scarf1

Indexed as

Gastrointestinal MicrobiomeInflammationLupus Erythematosus, SystemicAnimalsAutoimmune DiseasesAutoimmunityDisease Models, AnimalDysbiosisEfferocytosisFemaleMiceMice, KnockoutAutoimmuneGutInflammationLupusMicrobiomeSCARF1

Identifiers

PMID41673107
PMCPMC12972306

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.