Evidence map›Paper›PMID 41673115›Full record

ReviewCommunications biology2026

RNA editing in cardiovascular health and disease.

Xiaoxin Huang, Charles Solomon, David G McVey, Shu Ye

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoxin HuangDivision of Basic Medicine, Shantou University Medical College, Shantou, China.ORCID http://orcid.org/0009-0003-0402-3613
Charles SolomonDivision of Cardiovascular Sciences, University of Leicester, Leicester, UK.
David G McVeyDivision of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-6402-2546
Shu YeDivision of Basic Medicine, Shantou University Medical College, Shantou, China. shuye68@nus.edu.sg.ORCID http://orcid.org/0000-0002-4126-4278

Funding

British Heart Foundation (BHF) AA/18/3/34220British Heart Foundation (BHF) RE/24/130031, AA/18/3/34220British Heart Foundation (BHF) RG/16/13/32609, RG/19/9/34655, PG/16/9/31995, PG/18/73/34059, SP/19/2/344612MOH | National Medical Research Council (NMRC) MOH-001229, MOH-001479
6 · The paper itself

Abstract

Post-transcriptional RNA modifications can alter RNA structure, stability, localization, and function. Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that converts adenosine nucleotides in RNA to inosine nucleotides, catalyzed by adenosine-deaminase-acting-on-RNA (ADAR) enzymes. Recent studies have shown that A-to-I RNA editing is required for cardiovascular development and homeostasis whilst aberrant RNA editing plays a role in cardiovascular diseases. This article provides an overview of A-to-I RNA editing events that have been implicated in cardiovascular biology and disease. It also discusses harnessing RNA editing for cardiovascular disease biomarker development and engineering RNA editing for cardiovascular disease treatment.

Indexed as

Cardiovascular DiseasesRNA EditingAdenosineAnimalsHumansInosineAdenosineInosine

Identifiers

PMID41673115
PMCPMC12979643

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.