Evidence mapPaperPMID 41673147Full record

ArticleNature2026

Targeting excessive cholesterol deposition alleviates secondary lymphoedema.

Hwee Ying Lim, Yuning Zhang, Syaza Hazwany Mohammad Azhar, Chung Hwee Thiam, Michaela Taylor, Xuan Han Koh, Mohamed Ameen Shah Bin Mohamed Yunos, Shu Wen Tan, Sheau Yng Lim, Wei Siong Ong and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hwee Ying Lim *Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-3991-7855
Yuning Zhang *Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Syaza Hazwany Mohammad AzharImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Chung Hwee ThiamImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Michaela TaylorImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Xuan Han KohImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Mohamed Ameen Shah Bin Mohamed YunosImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Shu Wen TanImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Sheau Yng LimImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-7487-0373
Wei Siong OngImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0009-0002-2531-691X
Jasmine GohImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Si Hui NgImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Blake J CochranSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-9615-7939
Wai Kin ThamPrecision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Owen AngImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-7210-1586
Sheng Jie LimImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Tze Chin LimImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Yanjun ChenImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Sebastian Frederik MauseDepartment of Internal Medicine I, Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Federico TortaPrecision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Markus R WenkPrecision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-5447-7881
Kerry-Anne RyeSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-9751-917X
Bien Keem TanDepartment of Plastic, Reconstructive and Aesthetic Surgery, Singapore General hospital, Singapore, Singapore.
Veronique AngeliImmunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.ORCID 0000-0002-2759-3497

Funding

French governmentH.Y.L.National Research AgencyNMRC
6 · The paper itself

Abstract

Lymphoedema is a chronic debilitating disease caused by impaired lymphatic drainage and is characterized by tissue swelling, fat expansion, inflammation and fibrosis

Indexed as

CholesterolLymphedemaAdipocytesAdipose TissueAnimalsDisease Models, AnimalFemaleFibrosisHumansLymphatic VesselsMaleMiceMice, Inbred C57BLCholesterol

Identifiers

PMID41673147

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.