ArticleMikrochimica acta2026
MOF-on-MOF tandem nanozymes with autonomous substrate transformation for photoelectrochemical and paper-based colorimetric dual-mode aptasensing of neomycin.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The integration of nanotechnology with biocatalysis has advanced robust biosensors through self-cascade systems. Herein, a MOF-on-MOF tandem nanozyme (MOF-818/Cu-TCPP) engineered for autonomous substrate transformation is constructed for the photoelectrochemical (PEC) and paper-based colorimetric dual-mode aptasensor for neomycin (NEO). A polyvinyl pyrrolidone (PVP)-assisted method was employed to synthesize the core heterostructured MOF-818/Cu-TCPP tandem nanozyme, which exhibits integrated catechol oxidase and peroxidase-like activities. MOF-818 oxidizes 3,5-di-tert-butylcatechol (3,5-DTBC) to in-situ generate H2O2, which is used by Cu-TCPP to produce •OH radicals, oxidizing 4-choro-1-naphthol (4-CN) or 3,3’,5,5’-tetramethylbenzidine (TMB) to establish a “signal-off” state. For detection, a smart glutathione (GSH)-loaded ZIF-90/signal DNA (SA) probe is employed. Target NEO binding triggers probe attachment, and subsequent acidification releases GSH, which scavenges •OH, inhibiting precipitation/color development and switching the sensor to a “signal-on” state. The unique MOF-on-MOF structure ensures proximity between catalytic centers, enhancing cascade kinetics. The dual-mode sensor achieved detection limits of 0.023 pM (PEC) and 0.36 pM (colorimetric), with high specificity. This work provides a sensitive platform for antibiotic monitoring and a versatile strategy for designing self-sufficient nanozyme cascades based on hierarchical MOF architectures.
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