Evidence map›Paper›PMID 41673409›Full record

ArticleScientific reports2026

Sibutramine high-doses effects in cafeteria diet-induced obese rats.

Filipe M Ribeiro, Henny K Lima, Camila F A Ribeiro, Osmar N Silva, Guilherme Mendonça, Nathalia Cavichiolli de Oliveira, Rinaldo W Pereira, Alinne P de Castro, Octávio L Franco

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Filipe M Ribeiro *Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Henny K Lima *Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Camila F A RibeiroPostgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, Brazil.
Osmar N SilvaUniEvangélica, Evangelical University of Goiás, Anápolis, GO, 75083- 515, Brazil.
Guilherme MendonçaPostgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, Brazil.
Nathalia Cavichiolli de OliveiraPostgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, Brazil.
Rinaldo W PereiraCenter for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Alinne P de CastroPostgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, Brazil.
Octávio L FrancoCenter for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil. ocfranco@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, defined as excessive fat accumulation that impairs health, is a global challenge with high mortality rates. Sibutramine, a centrally acting anorectic, was widely used in obesity treatment due to its effects on appetite control and weight loss. It represented a key step in anti-obesity pharmacotherapy before being withdrawn in many countries. This study evaluates how a high sibutramine dose (10 mg.kg.day

Indexed as

Appetite DepressantsCyclobutanesObesityAnimalsBody WeightDietGastrointestinal MicrobiomeLiverMaleRatsAppetite DepressantsCyclobutanessibutramineCafeteria dietGut microbiotaLiver healthObesitySibutramine

Identifiers

PMID41673409
PMCPMC12966438

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.