Evidence map›Paper›PMID 41673728›Full record

ArticlePhysiological reports2026

Prognostic utility of the MECKI score in a mixed United States cohort.

Adarsh Mallepally, Kaivalya Dandamudi, Matthew G Kaye, Teymur Zavar, Bailey Parsons, Shreya Krishnamurthy, Hamang Patel, Ross Arena, Justin M Canada, Cory R Trankle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adarsh MallepallySchool of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Kaivalya DandamudiDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Matthew G KayeDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Teymur ZavarDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Bailey ParsonsDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Shreya KrishnamurthyDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Hamang PatelDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Ross ArenaDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Justin M CanadaDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Cory R TrankleDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-3891-7004

Funding

Wright Regional Center for Clinical and Translational ScienceUM1TR004360 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI FREDERICK Gerard MOELLER · 2023 to 2026
$16.3M
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation with Exercise CapacitY: EXCLAMATORY Longitudinal StudyK23HL166956 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Cory Trankle · 2023 to 2026
$726k
The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.K23HL159270 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Justin McNair Canada · 2023 to 2026
$596k
American Heart Association (AHA) 23IAUST1027504HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UM1TR004360HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL159270HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL166956NHLBI NIH HHS K23 HL166956
6 · The paper itself

Abstract

The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score has demonstrated prognostic utility in European and Asian cohorts with heart failure with reduced ejection fraction (HFrEF). We sought to evaluate its performance in an American cohort. We retrospectively identified patients who underwent cardiopulmonary exercise testing (CPX) at our institution in 2022-2024 with data to calculate the MECKI and CPX Risk scores. The primary endpoint was a composite of death, heart failure admission, heart transplantation, or ventricular assist device. Survival analysis was assessed via Kaplan-Meier curves and log-rank test, with ROC curves for comparison. Overall, 803 patients met criteria, with 451 (56%) female, 228 (28%) Black race, and median body mass index 29.4 (25.0-34.2) kg/m

Indexed as

Exercise TestHeart FailureAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesStroke VolumeUnited Statescardiopulmonary exercise testheart failureprognosis

Identifiers

PMID41673728
PMCPMC12894076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.