ArticleBMC microbiology2026
Multi-omics analysis of the gut-liver axis revealed the effects of different exercise interventions in NAFLD mice.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Metabolic dysfunction-associated steatotic liver disease: pathogenic mechanisms and exercise-induced molecular adaptations.Lipids in health and disease · 2026Review
- Non-pharmacological treatment of MASLD.Diabetologia · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundGrowing evidence indicates that gut microbiota may play a potential role in NAFLD. Exercise was recognized as an effective intervention for NAFLD, but the effects of these exercise modalities on gut microbiota in NAFLD remain unclear.
resultsC57BL/6J mice were divided into a normal diet control group (NC) and a high-fat diet (HFD) group. After 8 weeks on the HFD, the mice were further divided into three groups: HFD, HFD + AE (HAE), and HFD + RE (HRE), and treated for 12 weeks. Body weight and liver weight of the mice were measured, and samples (blood, liver, colon, and feces) were collected for serum and liver biochemical analysis. RT-PCR was performed to analyze genes related to intestinal barrier function, along with 16 S rRNA gene sequencing and RNA-seq analysis. AE and RE effectively mitigated HFD-induced increases in body weight and liver weight in mice. Serum and liver lipid levels, as well as liver enzyme levels, were significantly reduced following AE and RE interventions. Additionally, HFD-induced gut microbiota dysbiosis was reversed by AE and RE interventions. These interventions increased the abundance of the beneficial bacterium Odoribacter while eliminating the harmful bacteria Mycoplasma and Lachnoclostridiumgan. Specifically, AE increased the abundance of beneficial Candidatus_Sacleftimonas and reduced harmful Enterococcus and Dubosiella, while RE enhanced beneficial Christensenellaceae_R-7_group and reduced harmful Streptococcus and Lactococcus, thus modifying intestinal metabolism. Transcriptomic analysis revealed that liver improvement through AE and RE was associated with lipid metabolism and inflammatory genes, which exhibited consistent changes with the gut microbiota.
conclusionAE and RE could effectively prevent HFD-induced NAFLD and might serve as a reference for understanding the contribution of the gut microbiota due to their effects on altering liver lipid metabolism and maintaining gut microbiota homeostasis. Meanwhile, we suggest that combining AE and RE may result in more significant improvements.
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