Evidence map›Paper›PMID 41674145›Full record

ArticleClinical transplantation2026

Dual Kidney Transplantation Offers Prolonged Graft Survival.

Ekaterina Fedorova, Sofia Nehring Firmino, David Foley, Jacqueline Garonzik-Wang, Dixon Kaufman, Jon Odorico, David Aufhauser, Nikole A Neidlinger, Carrie Thiessen, Jennifer Philip and 6 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ekaterina FedorovaDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Sofia Nehring FirminoUniversity of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
David FoleyDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Jacqueline Garonzik-WangDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Dixon KaufmanDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Jon OdoricoDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
David AufhauserDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Nikole A NeidlingerDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Carrie ThiessenDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Jennifer PhilipDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Kelly M CollinsDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Josh MezrichDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
David Al-AdraDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-4469-6375
Didier MandelbrotDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-3326-8583
Brad C AstorDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Sandesh ParajuliDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-1667-7465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDual kidney transplantation (DKT), an uncommonly performed procedure, provides a unique opportunity to transplant nonstandard kidneys that might otherwise not be utilized. We compared perioperative and five-year posttransplant outcomes between DKT, and single kidney transplants (SKT) performed at our institution.

methodsWe analyzed all adult deceased donor kidney-alone transplant recipients at our center between 2001 and 2020. Recipients of pediatric en bloc kidney transplants were excluded. Perioperative outcomes of interest included delayed graft function (DGF), posttransplant length of stay (LOS), rehospitalization, and reoperation. Five-year outcomes included biopsy-proven acute rejection (AR), death-censored graft failure (DCGF), uncensored graft failure (UCGF), and death with functioning graft (DWFG).

resultsA total of 100 DKT and 3125 SKT recipients were included. DKT recipients were older (p < 0.001), more often male (68%), and more often underwent early steroid withdrawal (p = 0.04). In comparison to SKT, after adjustment for multiple variables, DKT was not independently associated with DGF (aOR: 1.25; 95% CI 0.76-2.08); prolonged LOS (linear coefficient 0.42; -0.9-1.7); reoperation (aOR: 0.73; 95% CI: 0.21-2.51) or rehospitalization (aOR 0.98; 95% CI: 0.55-1.74). However, within five years, DKT had a lower adjusted incidence rate ratio (aIRR) for AR (aIRR: 0.28; CI 0.12-0.64); DCGF (aIRR: 0.30; 95% CI 0.13-0.68), and UCGF (aIRR: 0.53; 95% CI: 0.33-0.86), without statistically significant differences in DWFG (aIRR: 0.83; 95% CI: 0.46-1.53).

conclusionIn selected recipients, DKT offered superior medium-term outcomes compared to SKT without compromising perioperative outcomes. DKT can mitigate concerns associated with medically complex donor kidneys, increase organ utilization, and increase access to transplantation.

Indexed as

Delayed Graft FunctionGraft RejectionGraft SurvivalKidney Failure, ChronicKidney TransplantationPostoperative ComplicationsTissue DonorsAdultFemaleFollow-Up StudiesGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedPrognosisdonors and donationgraft survivalrejection: acute

Identifiers

PMID41674145
PMCPMC12895095

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.