ArticleTurk gogus kalp damar cerrahisi dergisi2026
The effect of perioperative dexmedetomidine on early extubation time in patients undergoing pediatric cardiac surgical patients: A retrospective cohort study.
Article in Turk gogus kalp damar cerrahisi dergisi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to evaluate the effects of perioperative dexmedetomidine administration on opioid consumption and extubation timing in pediatric patients undergoing congenital heart surgery. Methods: In this single-center, retrospective cohort study, 112 pediatric patients (aged >1 month to <14 years) undergoing congenital cardiac surgery between January 2021-January 2022 were reviewed. Patients were divided into two groups; dexmedetomidine group (n=55) and a control group (n=57). Primary outcome measures included postoperative opioid consumption and mechanical ventilation duration. Secondary outcomes included high-flow oxygen therapy requirement, non-invasive ventilation, intensive care unit stay length, and reintubation rates. Results: Demographic characteristics were comparable between groups, although the Dex group had a higher proportion of complex surgical cases (risk adjustment for congenital heart surgery-1 category III: 34.5% vs. 25.9%, p=0.034). Mechanical ventilation duration was significantly longer in the Dex group (1.9±3.4 vs. 0.9±0.8 days, p=0.024), as was the requirement for high-flow oxygen therapy (56.4% vs. 31.0%, p=0.007). No significant differences were observed in non-invasive ventilation use, reintubation rates, or mortality. Conclusion: Perioperative dexmedetomidine was paradoxically associated with prolonged mechanical ventilation and increased postoperative respiratory support requirements. These findings suggest that dexmedetomidine should be employed as an adjunct rather than a substitute for opioids, particularly in patients undergoing complex procedures. Prospective randomized trials are warranted to refine dexmedetomidine's role in fast-track extubation protocols in this high-risk population.
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