ArticleResearch square2026
Concurrent Germline-Somatic Alterations and Associations with Cancer Outcomes: A Systematic Review of Concurrent Data Use.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Purpose: Despite routine clinical collection of germline and somatic data in patients diagnosed with cancer, little is known about how these data concurrently associate with outcomes. The purpose of this review is to map the landscape of concurrent germline-somatic alterations and their associations with translational and clinical outcomes to identify addressable gaps in reporting and considerations for future research. Design: All studies in patients with cancer published through February 2024 were included that contained both germline and somatic data and associations of concurrent germline and somatic attributes with outcomes (e.g. Results: Of the 8,613 studies screened, 197 met inclusion criteria. The most common concurrent germline-somatic alterations studied with respect to outcomes were germline Conclusions: These findings suggest that planning for concurrent germline-somatic data analysis during the initial design of a translational or clinical study could meaningfully improve current applications in cancer genetics.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.