Evidence map›Paper›PMID 41675281›Full record

ArticlePhenomics (Cham, Switzerland)2025

Metabolomics Reveals Reasons for the Efficacy of Acupuncture in Migraine Patients: The Role of Anaerobic Glycolysis and Mitochondrial Citrate in Migraine Relief.

Zishan Gao, Xianzhong Yan, Rui Wang-Sattler, Marcela Covic, Guang Yu, Feifei Ge, Jia Lin, Qin Chen, Juan Liu, Sapna Sharma and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phenomics (Cham, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Systemic AAV-hInternational journal of molecular sciences · 2026
    Article
  2. Journal of Zhejiang University. Science. B · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zishan GaoDepartment of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, 210029 Jiangsu China.ORCID 0000-0003-1299-0286
Xianzhong YanNational Center of Biomedical Analysis, Beijing, 100039 China.
Rui Wang-SattlerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-8794-8229
Marcela CovicResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Guang YuDepartment of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210029 Jiangsu China.
Feifei GeDepartment of Human Anatomy and Histoembryology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210029 Jiangsu China.ORCID 0000-0003-1336-8587
Jia LinDepartment of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041 Sichuan China.
Qin ChenThe Third Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, 310006 Zhejiang China.
Juan LiuNational Center of Biomedical Analysis, Beijing, 100039 China.
Sapna SharmaResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Sophie MolnosResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Brigitte KuehnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Rory WilsonResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Jonathan AdamResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Stefan BrandmaierResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Shuguang YuAcupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075 Sichuan China.ORCID 0000-0002-1413-8989
Fanrong LiangAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075 Sichuan China.ORCID 0000-0003-2210-2027
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-6986-9554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture is used worldwide to treat migraine, but its scientific mechanism remains unclear. Here, we report a Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-024-00205-6.

Indexed as

AcupunctureAnaerobic glycolysisCitrateLactic acidMetabolomicsMigraine

Identifiers

PMID41675281
PMCPMC12886611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.