ArticleBrain communications2026
Morphometric features enhance phenotype discrimination in frontotemporal lobar degeneration.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Frontotemporal lobar degeneration is associated with diverse clinical phenotypes underlain by multiple disease pathologies and genetic mutations for which traditional structural magnetic resonance imaging (MRI) analyses lack discriminatory sensitivity and specificity. Here, we use a data-driven multivariate method to extract a concise set of MRI-derived shape morphometric features and cross-sectionally examine the discriminatory capability of their unique combinations in three frontotemporal lobar degeneration clinical phenotypes. Patients with sporadic or familial frontotemporal lobar degeneration clinical syndromes across two cohorts (i.e. behavioral variant (
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