Evidence map›Paper›PMID 41675477›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026

Subclinical Changes in Cardiovascular Function During the Neonatal Period in Infants Born to Mothers With Diabetes.

Colman I Freel, Ibrahim Alhaji Mohammed, Alice Lynch, Gauri Murali, Uma Subrayan, Shivi Tripathi, Fiona Xu, Daniel K Benjamin, Rachel G Greenberg, Melissa M Campbell and 5 more

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Colman I FreelDepartment of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.
Ibrahim Alhaji MohammedDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Alice LynchDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Gauri MuraliDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Uma SubrayanDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Shivi TripathiDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Fiona XuDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Daniel K BenjaminDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Rachel G GreenbergDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Melissa M CampbellDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Rebekah A RapozaDepartment of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.
Corrine K HansonDepartment of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.
Paras Kumar MishraDepartment of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.
Daniel K BenjaminDuke Clinical Research Institute (CIF,* IAM, AL,† GM,† US,† ST,† FX,† RGG, MMC, DKB Jr), Department of Pediatrics (IAM, RGG, MMC, DKB Jr), Duke University School of Medicine, Durham, NC.
Ann L Anderson-BerryDepartment of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe link between maternal diabetes and congenital heart defects is well-established; however, few studies have investigated subclinical cardiovascular dysfunction at birth, which may serve as an early indicator of future risk.

methodsWe analyzed cardiovascular metrics, including heart rate and blood pressure during the postnatal hospital stay, in 1927 maternal-infant dyads at Nebraska Medicine (2012-2023), including 226 with gestational diabetes mellitus (GDM), 27 with type 1 DM (T1DM), 67 with type 2 DM (T2DM), and 1607 with no DM. Relationships between maternal diabetes subtype and neonatal cardiovascular metrics were examined using treatment effects modeling. Correlations between maternal glycemic burden, as assessed by average HbA1c and 1-hour oral glucose tolerance test (OGTT) during pregnancy, and newborn cardiovascular metrics were also evaluated.

resultsCompared with no DM, T1DM was associated with higher newborn systolic blood pressure (SBP) (+4.6 mm Hg, p = 0.002), pulse pressure (PP) (+3.1 mm Hg, p = 0.006), and SBP variability (+1.2 mm Hg, p = 0.048). T2DM was associated with higher newborn SBP (+2.9 mm Hg, p = 0.03) and PP (+2.0 mm Hg, p = 0.02) and lower SBP variability (-1.3 mm Hg, p = 0.049). There were sigsnificant positive correlations between maternal HbA1c and newborn heart rate (p = 0.009,

conclusionsThese findings indicate early subclinical changes in cardiovascular physiology in offspring of women with DM. The differential impacts of diabetes subtypes on newborn BP and strong link to maternal glycemic burden suggest severity and timing of maternal diabetes influence neonatal cardiovascular physiology.

Indexed as

cardiovascular diseasedevelopmental programmingdiabetesnewborn healthpregnancy

Identifiers

PMID41675477
PMCPMC12888998

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.