Evidence map›Paper›PMID 41675498›Full record

ArticleFrontiers in immunology2025

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with

Theresa Charlotte Christ, Justa Friebus-Kardash, Michael Bergerhausen, Abdelrahman Elwy, Hossam Abdelrahman, Lisa Holnsteiner, Tobias Tertel, Elisa Wiebeck, Ilka Geuer, Alexander Gerbaulet and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Theresa Charlotte Christ *Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Justa Friebus-Kardash *Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Michael BergerhausenInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Abdelrahman ElwyInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Hossam AbdelrahmanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Lisa HolnsteinerInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Tobias TertelInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Elisa WiebeckInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Ilka GeuerInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Alexander GerbauletInstitute for Immunology, Faculty of Medicine, Technische Universität (TU) Dresden, Dresden, Germany.
Philipp Alexander LangInstitute of Molecular Medicine II, Heinrich-Heine-University, Düsseldorf, Germany.
Karl Sebastian LangInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efficient phagocytosis of pathogens is a key effector function of the innate immune system. Impaired phagocytic activity can result in uncontrolled pathogen proliferation and life-threatening infections. However, reliable methods to detect early dysfunction of the phagocytic system

Indexed as

Cell NucleusListeria monocytogenesListeriosisLymphocytic choriomeningitis virusMacrophagesPhagocytosisAnimalsDisease Models, AnimalFemaleInterferon-gammaMiceMice, Inbred C57BLMice, KnockoutInterferon-gammaclodronateinterferon-gamma (IFN-γ)LCMVListeria monocytogenesmacrophagesphagocytosis

Identifiers

PMID41675498
PMCPMC12888213

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.