Evidence map›Paper›PMID 41675700›Full record

ArticleiMetaOmics2025

Precision microbial regulation: Strategies for modulating GIT microbiota for host health.

Pei Zhong, Qin Li, Yanmei Zhang, Cheng Guo, Mahmoud M Abdelsattar, Yanliang Bi

Abstract read
In one paragraph

Article in iMetaOmics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pei ZhongInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.
Qin LiInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.
Yanmei ZhangInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.
Cheng GuoInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.
Mahmoud M AbdelsattarInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.
Yanliang BiInstitute of Feed Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Beijing China.ORCID 0000-0001-8183-8208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of the gastrointestinal tract (GIT) microbiota and their associations with host well-being. Despite these insights, the precise regulation of GIT microbiota remains a significant challenge. Currently, microbial regulatory strategies, including fecal microbiota transplantation (FMT), synthetic microbial communities (SynComs), genetically engineered microorganisms (GEMs), phages, and nanomaterials, are increasingly utilized for their precise influence on GIT microbiota. This review emphasizes the necessity for developing targeted regulatory strategies in GIT and provides a comprehensive summary and comparison of these approaches to explore their regulatory potential. We discuss recent advancements in these strategies, focusing on their mechanisms, efficacy, safety considerations, clinical trials, and optimization at the application level. Finally, we highlight support methods for optimizing modulation strategies, including the timing of microbial regulation, the selection of microbial targets, and the importance of monitoring the gastrointestinal environment to guide effective microbial interventions.

Indexed as

FMTgenetically engineered microorganismsgut microbiotamicrobial regulationnanomaterialsphagessynthetic microbial communities

Identifiers

PMID41675700
PMCPMC12806292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.