ArticleAnnals of medicine and surgery (2012)2026
Evaluating the role of GnRH agonists in frozen embryo transfer cycles among polycystic ovary syndrome patients: a randomized clinical trial.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Objective: This study aims to determine whether pretreatment with gonadotropin-releasing hormone agonists (GnRHa) can improve clinical outcomes. Trial design and methods: This single-blinded, noninferiority randomized clinical trial aimed to compare the effects of GnRHa pretreatment on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer (FET). The study was conducted at the Avicenna Infertility Clinic (Tehran, Iran). A total of 284 participants were randomized into 2 groups of 142 individuals each; ultimately, 270 participants completed the trial - 133 in the GnRHa group and 137 in the no-GnRHa group. Outcomes included chemical, clinical, and ongoing pregnancy rates. Data were analyzed using Results: The chemical pregnancy rates in the intervention and comparison groups were 48.12% (95% CI: 39.80-56.54) and 45.98% (95% CI: 37.86-54.33), respectively, with no statistically significant difference between the groups ( Conclusions: The findings indicated that adding GnRHa to FET cycles in PCOS patients does not improve pregnancy outcomes, suggesting that clinicians may consider omitting GnRHa when appropriate. This supports more individualized, cost-effective treatment decisions without compromising effectiveness in routine fertility practice for selected cases.
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