Evidence map›Paper›PMID 41675873›Full record

ArticleAnnals of medicine and surgery (2012)2026

Dialyzer characteristics are associated with differential effects on intradialytic microvascular tissue perfusion.

Bgh Janssen, Y M Zhang, L Hur, M Moradshahi, A Akbari, O Mahmoud, C W McIntyre

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In one paragraph

Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bgh JanssenDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0003-3063-8200
Y M ZhangDepartment of Medical Biophysics, Western University, London, ON, Canada.
L HurDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0002-3737-540X
M MoradshahiDepartment of Medical Biophysics, Western University, London, ON, Canada.
A AkbariKidney Clinical Research Unit, London Health Sciences Centre, London, ON, Canada.
O MahmoudDepartment of Computer Sciences, Western University, London, ON, Canada.
C W McIntyreDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0002-3877-3135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: During hemodialysis (HD), microvascular perfusion is often compromised. These repeated ischemic insults can cause irreversible tissue damage in a variety of crucial organs. The role of dialyzer characteristics and general biocompatibility in this process is unknown. Clinical studies suggest a better biocompatibility profile for newer mid-cut-off (MCO) dialyzers when compared to conventional high-flux polysulfone (PSF). This study compared the effects of HD using either high-flux PSF or MCO dialyzers on microvascular perfusion in an established preclinical rat model of HD. Methods: HD using in-house manufactured mini-dialyzers was performed on 30 male Wistar Kyoto rats while simultaneously observing and quantifying microvascular perfusion in skeletal muscle using intravital microscopy. Results: HD using PSF dialyzers resulted in a significant reduction (25%) in microvascular perfusion, which was not found in HD using an MCO dialyzer. Blood pressure reduction was similar between the two groups, while the expected tachycardic response was better conserved in the MCO group. We found no difference in solute clearance or circulating electrolyte levels during the procedure. The mini-dialyzers effectively removed urea and creatinine, indicating the functionality of this experimental procedure. We observed increased plasma levels of C5b-9 following a PSF-HD, indicative of a higher bioactivation of the complement pathways. Conclusions: The results in our study show that this small animal model allows to preclinically evaluate new membrane materials and dialyzer designs

Identifiers

PMID41675873
PMCPMC12889412

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.