ArticleAmerican journal of translational research2026
Elevated preoperative inflammatory ratios (NLR/PLR) predict adverse pathology and poor surgical outcomes in metastatic renal cell carcinoma: a retrospective analysis.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify the clinical utility of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in metastatic renal cell carcinoma (mRCC).
methodsWe enrolled 240 RCC patients, including 100 primary RCC (pRCC) and 140 mRCC cases. Peripheral venous blood was sampled for NLR and PLR quantification. NLR/PLR correlations with clinicopathological features and their impacts on surgical outcomes were discussed.
resultsWe determined significant NLR and PLR elevations in mRCC versus pRCC cases. NLR had an area under the curve (AUC) of 0.710 while PLR exhibited an AUC of 0.716 in diagnosing mRCC. PLR correlated intimately with clinical staging and Fuhrman grading, while NLR was additionally linked to the metastatic site. In clinical stage discrimination, the AUC was 0.679 for NLR and 0.634 for PLR, with corresponding AUC of 0.656 and 0.612 in Fuhrman grade diagnosis. Additionally, the postoperative prognosis of mRCC patients was significantly and independently influenced by clinical staging, Fuhrman grading, NLR, and PLR.
conclusionNLR and PLR, showing up-regulated expression in mRCC, correlate intimately with advanced clinical staging and higher Fuhrman grading. Clinical stage III-IV, Fuhrman grade (3-4), elevated NLR (≥2.76), and high PLR (≥166.50) are predictors of unfavorable surgical outcomes in mRCC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.