Evidence map›Paper›PMID 41676474›Full record

ArticlebioRxiv : the preprint server for biology2026

Ketone body β-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism.

Leigh-Ana M Rossitto, Jamie Foo, Julia M Di Silvestri, Leanne Lehmann, Melina Brunelli, Yuhang Nie, Daniel Muñoz-Mayorga, Qiang Xiao, Anna Y Dai-Liu, Suborno Jati and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Leigh-Ana M RossittoDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7744-3630
Jamie FooDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Julia M Di SilvestriDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Leanne LehmannDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Melina BrunelliDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Yuhang NieDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Daniel Muñoz-MayorgaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Qiang XiaoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Anna Y Dai-LiuDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Suborno JatiDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Meghan RossiDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Richard DanemanDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
John C NewmanBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0002-8455-0100
Samuel A MyersDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Xu ChenDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.

Funding

GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Mechanisms by which the ketone body β-hydroxybutyrate counteracts tau pathogenesisR01AG074273 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Xu Chen · 2022 to 2026
$2.7M
Role of Testosterone in Modulating Tau Pathogenesis in FemalesR01AG078185 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Xu Chen · 2022 to 2026
$2.7M
Multidisciplinary training in basic and translational Alzheimer's disease researchT32AG066596 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 2020 to 2024
$2.2M
Dissecting the molecular mechanism of ketogenic metabolites in ADF99AG088570 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSSITTO, LEIGH-ANA MAE · 2025 to 2025
$48k
NIA NIH HHS F99 AG088570NIA NIH HHS R01 AG074273NIA NIH HHS R01 AG078185NIA NIH HHS T32 AG066596NIGMS NIH HHS T32 GM007752NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Metabolic interventions that induce ketosis, including ketogenic diets, caloric restriction, intermittent fasting, and exercise, show promise in the treatment of Alzheimer's disease (AD) and related tauopathies. β-hydroxybutyrate (βHB), the primary ketone body produced during ketosis, reproduces key features of these metabolic interventions, but the molecular mechanism underlying its neuroprotective properties is not fully understood. Here, we demonstrate that a βHB precursor diet is sufficient to ameliorate Tau pathophysiology in a tauopathy mouse model. Furthermore, across

Identifiers

PMID41676474
PMCPMC12889508

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.