Evidence map›Paper›PMID 41676565›Full record

ArticlebioRxiv : the preprint server for biology2026

S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states.

Yueh-Chien Lin, Takahiro Seno, Alan Y Hsu, Andréane Cartier, Andrew Kuo, Michel V Levesque, Avishek Ghosh, Ingo Fohmann, Victoria A Blaho, Sylvain Galvani and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yueh-Chien LinVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8997-2708
Takahiro SenoVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Alan Y HsuDepartment of Pathology, PhD Program in Immunology, Harvard Medical School, Boston, MA, USA.
Andréane CartierVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Andrew KuoVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Michel V LevesqueVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Avishek GhoshVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Ingo FohmannVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Victoria A BlahoCancer Metabolism and Microenvironment Program, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Sylvain GalvaniVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Reed CrockerVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Samuel W KazerDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
José Ordovás-MontañésDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Hongbo R LuoDepartment of Pathology, PhD Program in Immunology, Harvard Medical School, Boston, MA, USA.
Timothy HlaVascular Biology Program, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8355-4065

Funding

Novel Strategies to Improve Blood Transfusion PracticeP01HL158688 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Hongbo R Luo · 2022 to 2026
$12.9M
TRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2M
Enhancing neutrophil function in neutropenia-related pneumoniaR01HL092020 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2009 to 2022
$5.2M
Balancing epithelial cell resistance and resilience to respiratory viral infectionsR01HL162642 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Jose Manuel Ordovas-Montanes · 2023 to 2026
$3.4M
Myeloid sphingolipid regulation of tissue resolution and regeneration responsesR01AI173377 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Timothy Tun Hla · 2022 to 2026
$2.9M
Regulation of neutrophil death by GSDMD in Candida albicans infectionR01AI145274 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2M
Regulation of IL-1β bioactivity by Cysteine S-glutathionylationR01AI142642 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2M
Sphingolipid signaling in the endothelium during viral host defenseR01HL167723 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Timothy Tun Hla · 2024 to 2026
$2.1M
Cell-based high-throughput chemical genetic screening for GSDMD inhibitorsR01AI141386 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2022
$1.8M
NHLBI NIH HHS P01 HL158688NHLBI NIH HHS R01 HL092020NHLBI NIH HHS R01 HL162642NHLBI NIH HHS R01 HL167723NHLBI NIH HHS T32 HL066987NIAID NIH HHS R01 AI141386NIAID NIH HHS R01 AI142642NIAID NIH HHS R01 AI145274NIAID NIH HHS R01 AI173377
6 · The paper itself

Abstract

Initiation and resolution of inflammation are required to restore homeostasis. While neutrophils are classically viewed as short-lived effector cells that initiate inflammation, accumulating evidence suggests they can also contribute to resolution processes. Here, we identify neutrophil state characterized by long

Identifiers

PMID41676565
PMCPMC12889689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.