Evidence map›Paper›PMID 41676666›Full record

ArticlebioRxiv : the preprint server for biology2026

Microvascular network organization and hemodynamic perfusion protect the brain against hypoxia.

Thomas Ventimiglia, Frédéric Lesage, Andreas A Linninger

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Thomas VentimigliaDepartment of Biomedical Engineering, University of Illinois, Chicago, USA.ORCID 0009-0003-9951-0712
Frédéric LesageDepartment of Electrical Engineering, Polytechnique Montreal, Canada.ORCID 0000-0001-8241-7712
Andreas A LinningerDepartment of Biomedical Engineering, University of Illinois, Chicago, USA.ORCID 0000-0002-2694-630X

Funding

Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4M
Image-based cerebrovascular network snythesis(iCNS) to model Alzheimer's DiseaseR01AG079894 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ANDREAS A LINNINGER · 2023 to 2026
$2.9M
NIA NIH HHS R01 AG079894NINDS NIH HHS U19 NS123717
6 · The paper itself

Abstract

Mechanistic simulations of blood flow and oxygen exchange showed regions of cortical tissue tolerating substantial increase in local oxygen consumption (CMRO

Indexed as

capillarieshemodynamicsimagingneuropathologyneurovascular unit

Identifiers

PMID41676666
PMCPMC12889695

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.