ReviewJournal of the American Heart Association2026
Role of Caveolae and Caveolin in Vascular Physiology and Pathology.
Review in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo HeterozygousChildren (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolae, 50-100 nm cholesterol-rich plasma membrane invaginations, serve as critical signaling hubs in vascular cells. These structures-scaffolded by caveolin proteins (CAV1, CAV2, CAV3) and regulated by Cavins-orchestrate membrane dynamics, mechanotransduction, and lipid trafficking in endothelial cells, smooth muscle cells, and macrophages. In vascular physiology, caveolae modulate vascular tone, regulate lipoprotein metabolism, and mediate mechanosensation. In pathology, caveolae are implicated in atherosclerosis, pulmonary hypertension, and diabetic vasculopathy. This review synthesizes advances in caveolae biology, highlighting their roles in vascular homeostasis and disease. We propose caveolae-targeted therapies as promising strategies for cardiovascular disorders, contingent on resolving context-dependent signaling complexity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.