ArticleJournal of the American Heart Association2026
Age- and Sex-Specific Distribution and Reference Values of Coronary Artery Calcium in a Large Asymptomatic Japanese Cohort.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- A novel causative LMNA variant in acrogeria syndrome and literature review of genotype-phenotype correlations.Genes & diseases · 2027Article
- Warranty period of a zero coronary artery calcium score in Japanese adults.Japanese journal of radiology · 2026Article
- Tailoring Calcium Scores to the Race of a Nation Not a Region.Journal of the American Heart Association · 2026Article
- Article
- Coronary artery calcium and thoracic aortic calcification on non-ECG-gated chest CT in a large community-based cohort of Chinese men and women.Frontiers in cardiovascular medicine · 2026Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical use of coronary artery calcium (CAC) scoring for risk stratification in Japan is limited by the absence of population-specific reference data, as applying Western-derived thresholds is inappropriate because of known ethnic variations. This study aimed to establish the first comprehensive, age- and sex-specific CAC reference values for a healthy Japanese population.
methodsIn this single-center retrospective study, we analyzed data from 4891 asymptomatic Japanese adults (63.2% men; median age, 58 years) without a history of atherosclerotic cardiovascular disease or diabetes. Age- and sex-specific CAC percentile curves were generated using nonparametric regression modeling.
resultsMen exhibited a higher CAC burden than women, with scores increasing with age in both sexes. The relationship between detectable CAC (CAC >0) and age was nonlinear: concave down for men and concave up for women, indicating different progression patterns. Compared with MESA (Multi-Ethnic Study of Atherosclerosis) data, the Japanese cohort had a markedly lower CAC burden than White participants and systematically lower scores than Chinese American women.
conclusionsThis study provides the first large-scale, age- and sex-specific CAC reference values for a healthy Japanese population. The generated percentile curves offer a practical tool for clinicians to immediately assess a patient's CAC burden relative to their peers, underscoring that using foreign-derived thresholds is inappropriate for risk stratification in Japan.
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