Evidence map›Paper›PMID 41677104›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Dynamic Shifts in ER-Plasma Membrane Junctions Signaling Define Pro-Metastatic N-Glycosylation and Predict Prostate Cancer Progression.

Amanda J Macke, Tania Kamal, Taylor E Divita, Artem N Pachikov, Chad A LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean-Jack M Riethoven and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amanda J MackeDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Tania KamalDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Taylor E DivitaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Artem N PachikovDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Chad A LaGrangeDivision of Urologic Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Rajesh RavichandranThe Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Martha MortonThe Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Robert PowersThe Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Haowen QiuCenter for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Jean-Jack M RiethovenCenter for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Colm MorrisseyDepartment of Urology, University of Washington, Seattle, Washington, USA.
Melinda WojtkiewiczCardiOmics Program, Center For Heart and Vascular Research and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Rebekah L GundryCardiOmics Program, Center For Heart and Vascular Research and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Carol A CaseyDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Armen PetrosyanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0003-3895-3993

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver DiseaseR01AA020735 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASEY, CAROL A., MC NIVEN, MARK A. · 2011 to 2025
$8.1M
The role for alcohol-induced Golgi disorganization in the progression of prostate cancerR01AA027242 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PETROSYAN, ARMEN · 2019 to 2023
$1.7M
The impact of alcohol-induced ATF6-mediated ER stress and Golgi disorganization on pro-metastatic glycosylation of integrins in prostate cancerF31AA031186 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MACKE, AMANDA JESSIE · 2023 to 2024
$59k
BLRD VA I01 BX004171BLRD VA IK6 BX004853NIAAA NIH HHS F31 AA031186NIAAA NIH HHS F31AA031186NIAAA NIH HHS R01AA020735NIAAA NIH HHS R01 AA027242NIAAA NIH HHS R01AA027242NIGMS NIH HHS P20 GM113126NIH HHS 1P20GM113126NIH HHS R35-HL155460U.S. Department of Veterans Affairs I01BX004171VA Research Career Scientist Award IK6BX004853
6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most common and a leading cause of cancer-related deaths among men. Current screening methods lack precision in distinguishing aggressive cases, emphasizing a need for tissue-based biomarkers. Although Golgi disorganization, ER stress, and elevated high-mannose (Man) glycoproteins (e.g., Integrin α

Indexed as

Cell MembraneEndoplasmic ReticulumProstatic NeoplasmsBiomarkers, TumorDisease ProgressionGlycosylationGolgi ApparatusHumansMaleSignal TransductionBiomarkers, Tumorendoplasmic reticulum‐Plasma membrane junctionsgolgi disorganizationhigh‐Mannose glycansintegrinsmetastasisprostate cancer

Identifiers

PMID41677104
PMCPMC13248819

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.