Evidence map›Paper›PMID 41677571›Full record

ArticleThe Journal of cell biology2026

Spectrin coordinates cell shape and signaling essential for epidermal differentiation.

Arad Soffer, Aishwarya Bhosale, Roohallah Ghodrat, Marc Peskoller, Takeshi Matsui, Carien M Niessen, Chen Luxenburg, Matthias Rübsam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arad Soffer *Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0009-0000-5260-9481
Aishwarya Bhosale *Department Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0005-4759-9692
Roohallah GhodratDepartment Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0003-9568-6286
Marc PeskollerDepartment Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-8864-362X
Takeshi MatsuiSchool of Bioscience and Biotechnology, Tokyo University of Technology , Tokyo, Japan.ORCID 0000-0001-7118-0414
Carien M Niessen *Department Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4892-9391
Chen Luxenburg *Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-7801-3499
Matthias Rübsam *Department Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-0012-2601

Funding

Deutsche Forschungsgemeinschaft EXC 2030/CECAD - 390661388DFG-Forschungsgruppe 2743 NI 1234/7-1DFG-Schwerpunktprogramm 1782 NI 1234/6-2European Union NETSKINMODELS CA21108Israel Science Foundation 145/23University of Cologne
6 · The paper itself

Abstract

Cell shape and fate are tightly linked, yet how the cortical cytoskeleton integrates regulation of shape and fate remains unclear. Using the multilayered epidermis as a paradigm for cell shape-guided changes in differentiation, we identify spectrin as an essential organizer of the actomyosin cortex to integrate transitions in cell shape with spatial organization of signaling. Loss of αII-spectrin (Sptan1) in mouse epidermis altered cell shape in all layers and impaired differentiation and barrier formation. High-resolution imaging and laser ablation revealed that E-cadherin organizes gradients of cortical actin and spectrin into layer-specific submembranous networks with discrete structural and mechanical properties that coordinate cell shape and fate. This layer-specific organization dissipates tension and, in upper layers, retains activated growth factor receptor EGFR and the calcium channel TRPV3 at the membrane to induce terminal differentiation. Together, these findings reveal how polarized organization of the cortical cytoskeleton directs transitions in cell shape and cell fate at the tissue scale necessary to establish epithelial barriers.

Indexed as

Cell DifferentiationCell ShapeEpidermal CellsEpidermisKeratinocytesSignal TransductionSpectrinAnimalsCadherinsCytoskeletonErbB ReceptorsMiceCadherinsErbB ReceptorsSpectrin

Identifiers

PMID41677571
PMCPMC12898032

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.