Evidence map›Paper›PMID 41677615›Full record

ReviewCells2026

Exercise Protects Skeletal Muscle Fibers from Age-Related Dysfunctional Remodeling of Mitochondrial Network and Sarcotubular System.

Feliciano Protasi, Matteo Serano, Alice Brasile, Laura Pietrangelo

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feliciano ProtasiCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University Gabriele d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0002-0213-7591
Matteo SeranoDepartment of Molecular and Developmental Medicine, Molecular Medicine Section, University of Siena, I-53100 Siena, Italy.ORCID 0000-0002-4151-2980
Alice BrasileCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University Gabriele d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0009-0002-5927-6995
Laura PietrangeloCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University Gabriele d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0003-1197-7813

Funding

Italian Ministry of University and Research. PRIN 2022C878FP to F.P.
6 · The paper itself

Abstract

In skeletal muscles fibers, cellular respiration, excitation-contraction (EC) coupling (the mechanism that translates action potentials in Ca

Indexed as

AgingCalciumExerciseMuscle Fibers, SkeletalMuscular DiseasesAnimalsHumansMitochondrial MembranesMitochondria, MuscleSedentary BehaviorCalciumCa2+ release unit (CRU)excitation-contraction (EC) couplingmitochondriasarcoplasmic-reticulum (SR)store-operated Ca2+ entry (SOCE)transverse tubule (TT)triad

Identifiers

PMID41677615
PMCPMC12896787

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.