Evidence map›Paper›PMID 41677655›Full record

ArticleCells2026

Engineered CCR2 Cell Membrane-Wrapped Cepharanthine Liposomes for Potential Targeted Attenuation of Acute Lung Injury.

Yifan Qing, Wenbo Zhao, Liangliang Xue, Yu Luo, Yuhao Gao, Xiang Sun, Fan Li, Linxuan Dai, Jing Mo, Guoqing Xu and 5 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yifan QingSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Wenbo ZhaoInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Liangliang XueSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yu LuoInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yuhao GaoCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Xiang SunInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Fan LiSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Linxuan DaiSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Jing MoInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guoqing XuInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Zenghao BiInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0002-5811-0224
Suleixin YangInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0001-9898-1369
Woo Tiam HeeM. Kandiah Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Kajang 43000, Malaysia.
Jie LiInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Liang LengSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0002-9629-6808

Funding

China National Postdoctoral Program for Innovative Talents BX20240048China Postdoctoral Science Foundation 2025M773871National Key R&D Program of China 2025YFC3508601National Natural Science Foundation of China 82505368
6 · The paper itself

Abstract

Severe respiratory inflammation or viral infections can lead to acute lung injury (ALI), a disease characterized by diffuse inflammatory injury of the pulmonary epithelium and endothelium. Cepharanthine (CEP) is reported as a promising drug candidate due to its antiviral properties. However, CEP exhibits poor solubility and low bioavailability. Therefore, we developed a novel liposome, named CEP@LP-M

Indexed as

Acute Lung InjuryBenzylisoquinolinesCell MembraneLiposomesReceptors, CCR2AnimalsBenzodioxolesCell LineCytokinesLungMacrophagesMiceMice, Inbred C57BLBenzodioxolesBenzylisoquinolinesCcr2 protein, mousecepharanthineCytokinesLiposomesReceptors, CCR2acute lung injuryanti-inflammatorycepharanthineengineered CCR2 cell membraneliposomepotential targeted strategy

Identifiers

PMID41677655
PMCPMC12896890

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.