ArticleCells2026
PCIF1 Attenuates Type I Interferon Induction by Inhibiting IRF3 Activation in a Methyltransferase-Independent Manner.
Ryoya Kano, Chihiro Oyama, Chihiro Ikeda, Akiko Inujima, Keiichi Koizumi, Shinichiro Akichika, Tsutomu Suzuki, Aki Tanaka, Yoshiaki Ohkuma, Yutaka Hirose
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Ryoya KanoDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Chihiro OyamaDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Chihiro IkedaDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Akiko InujimaDepartment of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-Machi, Kahoku 920-0293, Japan.ORCID 0000-0003-0430-8419 Keiichi KoizumiDivision of Presymptomatic Disease, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-0349-4144 Shinichiro AkichikaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.ORCID 0000-0002-7660-2580 Tsutomu SuzukiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
Aki TanakaDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Yoshiaki OhkumaDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Yutaka HiroseDepartment of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Funding
Japan Science and Technology Agency JPMJSP2145the Japan Society for the Promotion of Science JP17K07282the Japan Society for the Promotion of Science JP18K06654the Japan Society for the Promotion of Science JP25K09954the Ministry of Education, Culture, Sports, Science, and Technology 24118003the Ministry of Education, Culture, Sports, Science, and Technology 25131704
6 · The paper itselfAbstract
PCIF1 is primarily recognized as an RNA methyltransferase that mediates
Indexed as
Interferon Regulatory Factor-3Interferon Type IMethyltransferasesAnimalsHumansImmunity, InnateMicePhosphorylationRNA, MessengerInterferon Regulatory Factor-3Interferon Type IIRF3 protein, humanMethyltransferasesRNA, Messengerantiviral responseinnate immunityIRF3m6AmmRNA modificationsPCIF1transcriptional regulationtype I interferon
Identifiers
PMID41677666
PMCPMC12896973
What Socratic holds
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