Isolation of Chicken Intestinal Glial Cells and Their Transcriptomic Response to LPS.

Jie Chen, Wenxiang Zhang, Xingxing Tian, Feng Zhang, Chunsheng Xu

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie ChenCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0000-1439-6593

Wenxiang ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0004-6008-2535

Xingxing TianCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0007-4365-760X

Feng ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0008-4836-9188

Chunsheng XuCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0007-0157-0469

Funding

Molecular mechanisms of interactions and contact between enteric glial cells and mucosal im-mune cells of the small Intestinal in chicken 32060782

6 · The paper itself

Abstract

Current research on glial cells has primarily focused on central nervous system glial cells (CNS glia), with relatively fewer studies on EGCs. Given the critical role of EGCs in maintaining intestinal homeostasis and neural function, this study aimed to investigate their immunomodulatory effects under inflammatory conditions. Primary EGCs were isolated and an inflammatory model was established by treatment with lipopolysaccharide (LPS). Following LPS induction, cellular samples were collected for transcriptomic analysis to identify differentially expressed genes. The analysis revealed that 88 genes were significantly altered, with 60 upregulated and 28 downregulated. Through Gene Ontology (GO) classification, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway mapping, and protein-protein interaction (PPI) network analysis, several key regulatory genes were identified: chemokine-related genes (

Indexed as

chickenEGCLPStranscriptome

Identifiers

PMID41677696

DOI10.3390/biology15030225

PMCPMC12896624

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.