ArticleEuropean journal of physical and rehabilitation medicine2025
Baseline functional oxygen uptake gain as a prognostic factor of center-based exercise responding in well-functioning older adults.
Article in European journal of physical and rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough the benefits of sustained exercise for cardiopulmonary health in older adults are well-established, it remains unclear which specific groups of older adults benefit most from exercise.
aimWe aimed to explore the relationship between baseline characteristics and peak oxygen uptake (peakVO<inf>2</inf>) improvements to identify potential exercise responders in older adults.
designThis was single-arm pre-post cohort study of exercise intervention, with post hoc dichotomization by responses of peakVO<inf>2</inf>.
settingThe study was conducted primarily at the geriatric rehabilitation clinic of Fuzhou University Affiliated Provincial Hospital. POPULATION: A total of 151 community-dwelling older adults with good functional status, with a mean age of 69 years.
methodAll participants underwent individualized, center-based, multicomponent exercise under supervision. And collecting data on functional oxygen uptake gain (ΔVO<inf>2</inf>/ΔWR), peakVO<inf>2</inf>, physical function, and laboratory indicators at baseline, 1-year, and 2-year. Participants were divided into exercise responders (ER, >2.5 mL/kg/min in absolute change of peakVO<inf>2</inf>) and exercise non-responders (ENR, ≤2.5 mL/kg/min in absolute change of peakVO<inf>2</inf>).
results151 and 91 participants were included in the 1-year and 2-year analysis, respectively. At baseline, the mean ΔVO<inf>2</inf>/ΔWR was 9.76±1.98 mL/min/W in ER and 11.26±1.50 mL/min/W in ENR, with a significant difference (P<0.001). The optimal baseline ΔVO<inf>2</inf>/ΔWR cut-off for discriminating 1-year ER was 9.310 mL/min/W. For 2-year ER, the corresponding cut-off value was 9.805 mL/min/W. A negative correlation was identified between baseline ΔVO<inf>2</inf>/ΔWR and the absolute changes in peakVO<inf>2</inf> at both the 1-year and 2-year follow-ups, using a multivariable linear regression model.
conclusionsOlder adults with lower ΔVO<inf>2</inf>/ΔWR gain the most from structured exercise. Future multicenter trials in more diverse populations are needed to confirm ΔVO<inf>2</inf>/ΔWR as a universal prognostic marker for exercise responders. CLINICAL REHABILITATION IMPACT: Older adults with low baseline ΔVO<inf>2</inf>/ΔWR should be particularly encouraged to participate in center-based exercise programs to maximize their cardiopulmonary benefits.
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