Evidence map›Paper›PMID 41677782›Full record

ArticleeLife2026

BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD.

Uyen Tran, Andrew J Streets, Devon Smith, Eva Decker, Annemarie Kirschfink, Lahoucine Izem, Jessie M Hassey, Briana Rutland, Manoj K Valluru, Jan Hinrich Bräsen and 6 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Uyen Tran *Department of Heart, Blood & Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0002-6498-9765
Andrew J Streets *Kidney Genetics Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Devon Smith *Kidney Genetics Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Eva DeckerMedizinische Genetik Mainz, Limbach Genetics, Mainz, Germany.
Annemarie KirschfinkDepartment of Human Genetics, RWTH University, Aachen, Germany.
Lahoucine IzemDepartment of Heart, Blood & Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0001-6498-0579
Jessie M HasseyDepartment of Heart, Blood & Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, United States.
Briana RutlandDepartment of Heart, Blood & Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, United States.
Manoj K ValluruKidney Genetics Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Jan Hinrich BräsenInstitute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.
Elisabeth OttDepartment of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Daniel EptingDepartment of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-7529-0845
Tobias EisenbergerMedizinische Genetik Mainz, Limbach Genetics, Mainz, Germany.
Albert C M OngKidney Genetics Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.ORCID https://orcid.org/0000-0002-7211-5400
Carsten BergmannMedizinische Genetik Mainz, Limbach Genetics, Mainz, Germany.ORCID https://orcid.org/0000-0002-6061-9759
Oliver WesselyDepartment of Heart, Blood & Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0001-6440-7975

Funding

The Role of Bicaudal-C in Polycystic Kidney DiseaseR01DK080745 · NIDDK · LSU HEALTH SCIENCES CENTER · PI WESSELY, OLIVER · 2009 to 2013
$1.7M
Bundesministerium für Forschung, Technologie und Raumfahrt 01GM1903GBundesministerium für Forschung, Technologie und Raumfahrt 01GM1903IDeutsche Forschungsgemeinschaft BE 3910/8-2Deutsche Forschungsgemeinschaft BE 3910/9-1Deutsche Forschungsgemeinschaft SFB 1453/Project-ID 431984000HORIZON EUROPE European Innovation Council TheRaCil,Grant Agreement #101080717Kidney Research UK PKD_RP_005_20211124NIDDK NIH HHS R01 DK080745NIDDK NIH HHS R01DK080745
6 · The paper itself

Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in

Indexed as

Polycystic Kidney, Autosomal DominantRNA-Binding ProteinsTRPP Cation ChannelsAnimalsDisease Models, AnimalHumansMiceMice, KnockoutProtein BindingXenopusBicc1 protein, humanBicc1 protein, mouseRNA-Binding ProteinsTRPP Cation ChannelsADPKDcell biologychronic kidney diseasedevelopmental biologyEO-ADPKDgenetic modifierhumanmouseRNA metabolismtranslational controlVEO-ADPKDxenopus

Identifiers

PMID41677782
PMCPMC12900513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.