Evidence map›Paper›PMID 41677783›Full record

ArticleeLife2026

Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.

Chaïma Azouzi, Katrin Schwank, Sophie Queille, Marta Kwapisz, Marion Aguirrebengoa, Anthony Henras, Simon Lebaron, Herbert Tschochner, Annick Lesne, Frederic Beckouët and 2 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chaïma AzouziUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0002-8816-7862
Katrin SchwankUniversität Regensburg, Regensburg Center of Biochemistry (RCB), Lehrstuhl Biochemie III, Regensburg, Germany.
Sophie QueilleUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0009-0007-1172-9883
Marta KwapiszUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0009-0008-9900-4103
Marion AguirrebengoaBigA, University of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0001-5205-9774
Anthony HenrasUniversität Regensburg, Regensburg Center of Biochemistry (RCB), Lehrstuhl Biochemie III, Regensburg, Germany.ORCID https://orcid.org/0000-0001-7785-9938
Simon LebaronUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0001-7348-2088
Herbert TschochnerUniversität Regensburg, Regensburg Center of Biochemistry (RCB), Lehrstuhl Biochemie III, Regensburg, Germany.ORCID https://orcid.org/0000-0002-3560-861X
Annick LesneLaboratoire de Physique Théorique de la Matière Condensée (LPTMC), Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0002-6647-612X
Frederic BeckouëtUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0002-9009-1852
Olivier GadalUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0001-9421-0831
Christophe DezUniversity of Toulouse, CNRS, Centre de Biologie Integrative (CBI), Toulouse, France.ORCID https://orcid.org/0000-0002-8526-3541

Funding

Deutsche Forschungsgemeinschaft TS35/15-1 695545Fondation ARC pour la Recherche sur le Cancer ARCPJA 20191209547Fondation ARC pour la Recherche sur le Cancer ARCPJA22020060002067Ligue Contre le Cancer 3FI14194UPALLigue Contre le Cancer TAGF23235
6 · The paper itself

Abstract

The RNA polymerase I (Pol I) enzyme that synthesizes large rRNA precursors exhibits a high rate of pauses during elongation, indicative of a discontinuous process. We show here that premature termination of transcription (PTT) by Pol I in yeast

Indexed as

RNA Polymerase IRNA, RibosomalSaccharomyces cerevisiaeTranscription, GeneticTranscription Termination, GeneticDNA, RibosomalHeterocyclic Compounds, 4 or More RingsSaccharomyces cerevisiae ProteinsBMH-21DNA, RibosomalHeterocyclic Compounds, 4 or More RingsRNA Polymerase IRNA, RibosomalSaccharomyces cerevisiae ProteinsBMH-21geneticsgenomicspremature termination of transcriptionrDNA transcriptionRNA polymerase IS. cerevisiae

Identifiers

PMID41677783
PMCPMC12900514

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.