Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jing SunDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health University, Baltimore, Maryland, USA.ORCID 0000-0003-3741-0962
Jorge R KizerDepartment of Medicine (Cardiology), San Francisco Veterans Affairs Health Care System and University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-9936-7803
Katherine C WuDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-4958-5145
Wendy S PostDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health University, Baltimore, Maryland, USA.ORCID 0000-0002-8655-5204
David C SamuelsDepartment of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
Todd HulganDepartment of Medicine (Infectious Diseases), Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-3339-067X
Brad AouizeratDepartment of Oral and Maxillofacial Surgery, New York University, New York, New York, USA.
Frank PalellaDepartment of Medicine (Infectious Diseases), Northwestern University, Chicago, Illinois, USA.
Shehnaz HussainDepartment of Public Health Sciences, School of Medicine and Comprehensive Cancer Center, University of California, Davis, Davis, California, USA.
Jeremy MartinsonDepartment of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4673-7238
Nicole D ArmstrongDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6483-4560
Claudia MartinezDepartment of Medicine (Cardiology), University of Miami Miller School of Medicine, Miami, Florida, USA.
Caitlin A MoranDepartment of Medicine (Infectious Diseases), Emory University School of Medicine, Atlanta, Georgia, USA.
Alan HinderliterDepartment of Medicine (Cardiology), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3262-5668
Yasmeen GolzarDepartment of Medicine (Cardiology), Cook County Health, Chicago, Illinois, USA.
Federico M AschDepartment of Medicine (Cardiology), MedStar Health Research Institute, MedStar Washington Hospital Center, Washington, DC, USA.ORCID 0000-0002-1744-5271
Jason LazarDepartment of Medicine (Cardiology), SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Carlos J RodríguezDepartment of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York, USA.
Todd T BrownDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health University, Baltimore, Maryland, USA.ORCID 0000-0001-8599-278X
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Renee A. Heffron · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)National Cancer Institute (NCI)National Heart, Lung, and Blood Institute (NHLBI)National Institute of Dental & Craniofacial Research (NIDCR)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)National Institute of Mental Health (NIMH)National Institute of Neurological Disorders and Stroke (NINDS)National Institute of Nursing Research (NINR)National Institute on Ageing (NIA)National Institute on Alcohol Abuse and Alcoholism (NIAAA)National Institute on Deafness and Other Communication Disorders (NIDCD)National Institute on Drug Abuse (NIDA)National Institute on Minority Health and Health Disparities (NIMHD)NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS K01 AI162247NIAID NIH HHS K01AI162247NIAID NIH HHS K24 AI120834NIAID NIH HHS K24AI120834NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI124414NIDDK NIH HHS R21 DK101342NIH HHSNIH HHS U01-HL146192NIH HHS U01-HL146193NIH HHS U01-HL146194NIH HHS U01-HL146201NIH HHS U01-HL146202NIH HHS U01-HL146203NIH HHS U01-HL146204NIH HHS U01-HL146205NIH HHS U01-HL146208NIH HHS U01-HL146240NIH HHS U01-HL146242NIH HHS U01-HL146245NIH HHS U01-HL146333NIH HHS U01HL146333NIMH NIH HHS P30 MH116867Office of AIDS Research (OAR) KL2-TR001432Office of AIDS Research (OAR) P30-AI-027767Office of AIDS Research (OAR) P30-AI-050409Office of AIDS Research (OAR) P30-AI-050410Office of AIDS Research (OAR) P30-AI-073961Office of AIDS Research (OAR) P30-AI-124414Office of AIDS Research (OAR) P30-MH-116867Office of AIDS Research (OAR) TL1-TR001431Office of AIDS Research (OAR) UL1-TR000004Office of AIDS Research (OAR) UL1-TR001409Office of AIDS Research (OAR) UL1-TR001881Office of AIDS Research (OAR) UL1-TR003098
6 · The paper itself
Abstract
backgroundCardiac dysfunction is more common in people with HIV (PWH) than those without HIV (PWoH), with mitochondrial dysfunction implicated in pathogenesis. We investigated whether variations in mitochondrial DNA (mtDNA) and certain dideoxynucleoside analogs (D-drugs) relate to left ventricular diastolic dysfunction (LVDD) in PWH.
methodsWe included individuals with echocardiograms from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. LVDD was defined using characterizing heart function on antiretroviral therapy criteria. mtDNA haplogroups were inferred using HaploGrep. Separate exploratory multivariable logistic regressions examined associations between LVDD and African (L0L1, L2, L3, or "other") or European haplogroups (UK, H, JT, or "other"), D-drugs, and their interactions. No adjustments were made for multiple comparisons.
resultsAmong 842 men (455 PWH and 387 PWoH) and 898 women (620 PWH and 278 PWoH), LVDD prevalence was 29% in women and 24% in men. Among non-Hispanic White men with HIV, European haplogroup H was associated with lower odds of LVDD (odds ratio [OR], 0.50; 95% CI, 0.26-0.93), while haplogroup clade JT was associated with increased odds (OR, 2.09; 95% CI, 1.00-4.36). In men with HIV, D-drug exposure was associated with increased odds of LVDD (OR, 1.94; 95% CI, 1.21-3.13). No significant associations were observed between haplogroups and LVDD in women. HIV serostatus modified the association of haplogroup L2 (pinteraction = 0.036) and L3 (pinteraction = 0.045) with LVDD in women.
conclusionsMitochondrial genetic variation and D-drug use were associated with altered LVDD risk in men with HIV, highlighting potential biological mechanisms that may be targeted for surveillance or therapeutic strategies.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.