Evidence map›Paper›PMID 41677916›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Prevalence of bone mineral disease in children with acute kidney disease on continuous kidney replacement therapy: a case-control study.

Mugdha V Rairikar, Siddharth P Jadhav, Matthew Ditzler, Curtis E Kennedy, Peace D Imani, Ayse Akcan Arikan, Poyyapakkam Srivaths

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mugdha V RairikarDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, 1102, Bates Street, Suite 245, Houston, TX, 77030, USA. mvrairik@texaschildrens.org.ORCID http://orcid.org/0000-0002-6882-8088
Siddharth P JadhavDepartment of Radiology, Baylor College of Medicine, Houston, TX, USA.
Matthew DitzlerDepartment of Radiology, Baylor College of Medicine, Houston, TX, USA.
Curtis E KennedyDivision of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Peace D ImaniDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, 1102, Bates Street, Suite 245, Houston, TX, 77030, USA.
Ayse Akcan ArikanDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, 1102, Bates Street, Suite 245, Houston, TX, 77030, USA.
Poyyapakkam SrivathsDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, 1102, Bates Street, Suite 245, Houston, TX, 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of continuous kidney replacement therapy (CKRT) with regional citrate anticoagulation (RCA) on bone mineral disease of acute kidney injury-disease (AKI-D) has not been well studied. We designed a case-control study to evaluate osteopenia and mineral balance markers in prolonged CKRT with RCA.

methodsCases were patients with AKI-D on CKRT with RCA; controls were patients immobilized ≥ 28 days, matched with propensity scoring. Data collected at day 0, 14, and 28. Two blinded radiologists independently evaluated for osteopenia/fractures.

resultsOsteopenia in cases was higher at day 14 (20/53 cases vs. 10/49 controls, p 0.05), and day 28 (21/53 cases vs. 11/49 controls, p 0.06). Younger age, CKRT, gastrointestinal/liver comorbidity increased the odds of osteopenia in cases and controls. Citrate rate adjusted for blood flow had higher odds of day 28 osteopenia. New fractures were higher in cases (13/53) than controls (3/49) (p 0.01). Younger age and osteopenia at baseline, day 14, and 28 had higher odds of fractures in cases. There was moderate agreement among radiologists for osteopenia (Kappa 0.62).

conclusionsThis is an important comparative study in children with AKI-D on prolonged CKRT and bone complications. Increased fractures and osteopenia were noted in children undergoing prolonged CKRT compared to immobilization alone. Increased risk of fractures was associated with the presence/persistence of osteopenia and younger age. Further research is needed to elucidate underlying mechanisms and optimize management strategies for osteopenia and fractures in patients receiving prolonged CKRT.

Indexed as

Acute Kidney InjuryAnticoagulantsBone Diseases, MetabolicContinuous Renal Replacement TherapyFractures, BoneAdolescentCase-Control StudiesChildChild, PreschoolCitric AcidFemaleHumansMalePrevalenceRisk FactorsAnticoagulantsCitric AcidAcute kidney diseaseBone mineral diseaseFractureOsteopeniaProlonged continuous kidney replacement therapy

Identifiers

PMID41677916

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.