Evidence map›Paper›PMID 41677964›Full record

ArticleBiogerontology2026

Oxidative stress in frailty among older adults: are malondialdehyde and superoxide dismutase the key biomarkers?

Yuyang Zhang, Jiali Zheng, Xiaoxiao Zhang, Yanwen Zhang, Kexin Zhang, Yujiao Hao, Yang Li, Tingting Ma, Xinyu Bai, Yulu Wang and 3 more

Abstract read
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In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuyang Zhang *Intelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Jiali Zheng *Intelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Xiaoxiao Zhang *Intelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Yanwen ZhangIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Kexin ZhangIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Yujiao HaoIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Yang LiIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Tingting MaIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Xinyu BaiIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China.
Yulu WangIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China. yulu_09@126.com.
Yaogang WangSchool of Public Health, Tianjin Medical University, Tianjin, China. YaogangWANG@tmu.edu.cn.
Qi LuIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China. luqi8674866@hotmail.com.
Yue ZhaoIntelligent Nursing Research Center, Tianjin Medical University, Tianjin, China. yuezhao35@hotmail.com.

Funding

National Natural Science Foundation of China 72204186National Natural Science Foundation of China 72274134National Natural Science Foundation of China 72404208the National Science and Technology Innovation 2030, Noncommunicable Chronic Diseases-National Science and Technology Major Project No.2024ZD0524300, 2024ZD0524301Tianjin Medical University Nursing Discipline Enhancement Program No. 2024XKHL31
6 · The paper itself

Abstract

Frailty is a significant health issue among older adults. Oxidative stress (OS), indicated by elevated malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) activity, is implicated in age-related diseases. This study aims to explore the relationship between OS biomarkers, MDA and SOD, and frailty among older adults. This study investigated the association between MDA, SOD, and frailty in 3181 older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty was assessed using a 37-variable frailty index. Logistic regression and restricted cubic spline (RCS) analysis were employed to examine the relationship between OS biomarkers and frailty, adjusting for demographic, socioeconomic, lifestyle, and physically relevant factors. This study has found that higher MDA levels were significantly associated with increased frailty risk (OR = 1.06, 95% CI: 1.03-1.09), while SOD activity showed no independent association. The threshold point for MDA was 3.37 (P = 0.003). This study highlights that MDA is independent OS biomarker related to frailty in community-dwelling older adults, suggesting plasma MDA as OS biomarker could potentially aid in the identification and clinical management of frailty.

Indexed as

AgingFrail ElderlyFrailtyMalondialdehydeOxidative StressSuperoxide DismutaseAgedAged, 80 and overBiomarkersFemaleHumansLongitudinal StudiesMaleBiomarkersMalondialdehydeSuperoxide DismutaseFrailtyMalondialdehydeOxidative stressSuperoxide dismutase

Identifiers

PMID41677964

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.