Evidence map›Paper›PMID 41678045›Full record

ArticleMagma (New York, N.Y.)2026

Adaptation of an arterial spin labeling sequence for the assessment of brain perfusion on a 0.35 T MR-Linac.

Philipp Wallimann, Philip Wild, Petros Martirosian, Fritz Schick, Michael Mayinger, Andreas Boss, Andrea Bink, Matthias Guckenberger, Stephanie Tanadini-Lang, Nicolaus Andratschke and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05565326 (Pilot Study on Response Assessment During MR-guided Radiation Therapy for Glioblastoma Multiforme), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05565326 recruitingnot on this map

Pilot Study on Response Assessment During MR-guided Radiation Therapy for Glioblastoma Multiforme

TypeobservationalSponsorUniversity of ZurichRan2022 to 2025Enrolled20ConditionsGlioblastoma MultiformeArmsLow field (0.35 T) MR-images of the brain at a MRIdian® linac system
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Philipp Wallimann *Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland. philipp.wallimann@usz.ch.ORCID http://orcid.org/0000-0002-7110-6617
Philip Wild *Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.
Petros MartirosianSection of Experimental Radiology, Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.
Fritz SchickSection of Experimental Radiology, Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.
Michael MayingerDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.
Andreas BossInstitute for Diagnostic and Interventional Radiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Andrea BinkDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.
Stephanie Tanadini-LangDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.
Nicolaus AndratschkeDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.
Bertrand PouymayouDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 325230_200581
6 · The paper itself

Abstract

objectiveHybrid MR-Linac devices allow the acquisition of functional MR images during a regular radiotherapy treatment workflow, which could improve target delineation and response assessment. In this work, we investigate the feasibility of acquiring arterial spin labeling (ASL) perfusion images on a 0.35 T MR-Linac. MATERIALS AND

methodsA signal model for the flow-sensitive alternating inversion recovery (FAIR) balanced steady-state free precession (bSSFP) ASL sequence was introduced and an optimized set of sequence parameters for 0.35 T was determined. The signal dependence on the sequence parameters using the MR-Linac was examined in the brain of two healthy volunteers. Repeatability of cerebral blood flow (CBF) measurements with an adjusted MR-Linac protocol were compared to ASL images from a clinical 3 T scanner in six healthy volunteers that were scanned twice on each device.

resultsThe signal model described the observed measurements well, except for the dependence on inversion time. CBF values in gray and white matter in the six volunteers were systematically higher than at the 3 T scanner, but they had a similar percentage repeatability coefficient of 16-17%.

conclusionAn adjusted 10-min FAIR bSSFP ASL protocol on a 0.35 T MR-Linac yielded repeatable CBF measurements. (glinicaltrials.gov NCT05565326, submitted 2022-09-29).

Indexed as

Arterial spin labelingCBFFAIRMR-LinacPerfusion imaging

Identifiers

PMID41678045

What Socratic holds

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Registered trials

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