Evidence map›Paper›PMID 41678301›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation.

Navroop K Dhaliwal, Octavia Yifang Weng, Ai Tian, Aditi Aggarwal, Mai Ahmed, Guoria Sun, Afrin Bhattacharya, Wendy W Y Choi, Haruka Nishimura, Pragnya Chakraborty and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Navroop K Dhaliwal *Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Octavia Yifang Weng *Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Ai TianProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Aditi AggarwalProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Mai AhmedProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Guoria SunProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Afrin BhattacharyaProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Wendy W Y ChoiProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Haruka NishimuraProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Pragnya ChakrabortyProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Xiaoxue DongProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Yuncheng WuDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.ORCID 0000-0003-4581-6524
Michael D WilsonDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-4015-3066
Lu-Yang WangProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5399-944X
Luis F ParadaBrain Tumor Center, Memorial Sloan Kettering Cancer Center, New York NY 10065.ORCID 0000-0003-2295-1432
Julien MuffatProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Yun LiProgram in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5849-5910

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Isolation, characterization and translational development of glioma stem cellsR35CA210100 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PARADA, LUIS FERNANDO · 2017 to 2023
$7.4M
Canada Research Chairs (CRC) N/ACIHR | Institute of Cancer Research (IC) PJT-180565Epilepsy Canada (Épilepsie Canada) N/AHHS | NIH | National Cancer Institute (NCI) 5 R35 CA210100-07NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA210100Scottish Rite Charitable Foundation of Canada (SRCFC) N/A
6 · The paper itself

Abstract

Mutations in the phosphatase and tensin homolog (

Indexed as

Actin-Related Protein 2-3 ComplexMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Neural Stem CellsNeuronsPTEN PhosphohydrolaseActinsHumansSignal TransductionActin-Related Protein 2-3 ComplexActinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2PTEN PhosphohydrolasePTEN protein, humanactinhuman pluripotent stem cellsmTOR signalingneurodevelopmental disordersPTEN

Identifiers

PMID41678301
PMCPMC12912955

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.