In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Huan Zhao *Chinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-6319-949X Hui Chen *Chinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Zhixin Kang *Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID 0009-0007-6611-9310 Xiuzhen HuangChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-4087-8964 Jingting ZhuChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0008-2133-7338 Zixin LiuChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-1085-8911 Xiuxiu LiuChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-3807-5417 Ximeng HanChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Jie LuDepartment of Gastroenterology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.ORCID 0000-0002-1814-2125 Bin ZhouChinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-5278-5522 Funding
CAS Project for Young Scientists in Basic Research YSBR-012CAS Strategic Priority Research Program of CAS XDB0990101MOST | National Key Research and Development Program of China (NKPs) 2024YFA1803302 2023YFA1800700NSF of China 82088101 32370802Shanghai Municipal Science and Technology Major Project N/Athe New Cornerstone Science Foundation through the New Cornerstone Investigator Program N/Athe XPLORER PRIZE N/AYouth Innovation Promotion Association CAS, Shanghai Pilot Program for Basic Research - CAS, Shanghai Branch JCYJ-SHFY-2021-0
6 · The paper itselfAbstract
Pancreatic beta cell generation and proliferation primarily rely on the self renewal of preexisting beta cells, making precise quantification of beta cell proliferation essential for understanding pancreatic homeostasis and pathogenesis. However, previous methods had limitations and were unable to trace beta cell proliferation in vivo over extended periods. Here, we developed beta cell ProTracer, a genetic system that uses dual recombinase technology to enable continuous and cell type-specific recording of beta cell proliferation in mice. The beta cell ProTracer system allows for the quantification of the proliferation rate of adult pancreatic beta cells during homeostasis and in response to injury or drug treatment. Clonal analysis of the proliferated beta cell population reveals a uniform proliferative capacity among these cells. Our findings enhance the understanding of beta cell proliferation dynamics in homeostasis, repair, and regeneration.
Indexed as
Cell ProliferationInsulin-Secreting CellsAnimalsMicediabetesdual recombinaseslineage tracingpancreatic beta cell proliferation
Identifiers
PMID41678310
PMCPMC12912958
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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