SynthesisNeuroImage. Clinical2026
Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis.
Synthesis in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Major Depressive Disorder (MDD) diagnoses have drastically increased in the United States from 6.5% to 21-30% since 2019, burdening individuals and society alike. Despite considerable efforts to understand the pathogenesis of MDD, the heterogeneity of the disorder has made it difficult to delineate its underpinnings, highlighting the need for biomarker identification. This study assessed the concentrations of key neurometabolites in the anterior cingulate cortex (ACC) in people with MDD (average n = 496) compared to healthy controls (average n = 404). We conducted a systematic review that ultimately led to the inclusion of n = 43 proton magnetic resonance spectroscopy (
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