Evidence map›Paper›PMID 41679435›Full record

ArticleMolecular metabolism2026

Maternal obesity decreases offspring lifespan.

Eric Moore, Ramasamy Selvarani, Kavitha Kurup, Michael Chan, Mani Saminathan, Natesan Pazhanivel, Kai Ding, Alexandra Ford, Brianne M Taylor, Karen Jonscher and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Eric MooreDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Ramasamy SelvaraniDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Kavitha KurupDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Michael ChanDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Mani SaminathanDivision of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Nainital, Uttarakhand, 263 138, India.
Natesan PazhanivelMadras Veterinary College, TANUVAS, Chennai, Tamil Nadu, India.
Kai DingDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Alexandra FordAntech Diagnostics, Mars Petcare Science & Diagnostics, Fountain Valley, CA, USA.
Brianne M TaylorDepartment of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK, USA.
Karen JonscherDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Department of Obstetrics and Gynecology, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Arlan RichardsonDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA.
Jacob E FriedmanDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Archana UnnikrishnanDepartment of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, OK, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, USA. Electronic address: archana-unnikrishnan@ou.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data in mice, nonhuman primates, and in humans demonstrate that exposure to maternal obesity increases the risk of multiple diseases in offspring. However, little is known about the aging effects of maternal obesity on the offspring. This study shows that maternal obesity significantly reduced the lifespan of both male and female mice born to obese dams despite being weaned onto a healthy diet at three weeks of age. This reduction in longevity was linked to an increase in age-related fibrotic pathology across multiple organs, e.g., liver, heart, and kidney. Gompertz analysis of the lifespan data showed that maternal obesity offspring have reduced lifespan due to detrimental changes established early during development rather than factors that modify aging later-in-life. These findings are translationally significant as they demonstrate that the growing prevalence of MO may lead to a decrease in overall lifespan and increase in age-related diseases in the next generation.

Indexed as

LongevityObesityPregnancy in ObesityPrenatal Exposure Delayed EffectsAgingAnimalsDevelopmental Origins of Health and DiseaseFemaleFibrosisMaleMiceMice, Inbred C57BLPregnancyAgingFibrosisLifespanWestern diet

Identifiers

PMID41679435
PMCPMC12945535

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.