Evidence map›Paper›PMID 41679675›Full record

ArticleNeurobiology of disease2026

Distinct neuronal mechanisms for motor impairment and seizures in a novel mouse model of SCN8A epileptic encephalopathy.

Midhun N K Anne, Laura Kakuk-Atkins, Jason Kaplan, Adam S Deardorff, Meretta A Hanson, Aidan C Johantges, Alec H Marshall, Stephen J Kolb, Jason C Wester, Jacy L Wagnon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Midhun N K AnneDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology (MCDB) graduate program, The Ohio State University, Columbus, OH 43210, USA.
Laura Kakuk-AtkinsDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jason KaplanDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Adam S DeardorffDepartment of Clinical Neurosciences; Wright State University Boonshoft School of Medicine; Dayton, OH 45435, USA; Department of Neuroscience, Cell Biology, and Physiology; Wright State University Boonshoft School of Medicine; Dayton, OH 45435, USA.
Meretta A HansonDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Neuroscience graduate program, The Ohio State University, Columbus, OH 43210, USA.
Aidan C JohantgesDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Alec H MarshallDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Stephen J KolbDepartment of Neurology, The Ohio State University, Columbus, OH 43210, USA; Department of Biological Chemistry & Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Jason C WesterDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jacy L WagnonDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology (MCDB) graduate program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: Jacy.Wagnon@osumc.edu.

Funding

Understanding the role of SCN8A in developmental and epileptic encephalopathyR01NS131319 · NINDS · OHIO STATE UNIVERSITY · PI Jacy Lee Wagnon · 2024 to 2026
$1.1M
Reversibility of Dravet syndromeR21NS098003 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEISLER, MIRIAM H · 2017 to 2018
$427k
NINDS NIH HHS R01 NS131319NINDS NIH HHS R21 NS098003
6 · The paper itself

Abstract

Variants in the voltage-gated sodium channel gene SCN8A cause a severe developmental and epileptic encephalopathy (DEE) characterized by treatment-resistant seizures, developmental delay, long-term cognitive and motor impairment, and elevated risk of premature death. The most common comorbidity is motor impairment, including hypotonia, movement disorders like ataxia, and weakness. To date, mouse models of SCN8A DEE have recapitulated seizures and early death, but have not exhibited motor impairment. We developed a novel conditional mouse model of SCN8A DEE with the patient mutation p.Thr767Ile (T767I). Ubiquitous expression of the T767I allele with Sox2-Cre (Scn8a

Indexed as

EpilepsyMovement DisordersNAV1.6 Voltage-Gated Sodium ChannelNeuronsSeizuresAnimalsDisease Models, AnimalMiceMice, TransgenicMutationNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseDevelopmental and epileptic encephalopathyEpilepsyIon channelMovement disorderNav1.6Sodium channel

Identifiers

PMID41679675
PMCPMC13141817

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.